Background: Knee osteoarthritis (OA) is a common disabling disease involving the entire joint tissue, and its onset\nand progression are affected by many factors. However, the current number of studies investigating the relationship\nbetween subchondral trabecular bone (STB), knee alignment, and OA severity is limited. We aimed to investigate the\nvariation in tibial plateau STB microarchitecture in end-stage knee OA patients and their association with knee\nalignment (hip-knee-ankle, HKA, angle) and OA severity.\nMethods: Seventy-one knee OA patients scheduled for total knee arthroplasty (TKA) underwent preoperative\nradiography to measure the HKA angle and Kellgren-Lawrence grade. Tibial plateaus collected from TKA were\nscanned using micro-computed tomography to analyze the STB microarchitecture. Histological sections were\nused to assess cartilage degeneration (OARSI score). Correlations between the HKA angle, OA severity (OARSI\nscore, Kellgren-Lawrence grade), and STB microarchitecture were evaluated. Differences in STB microstructural\nparameters between varus and valgus alignment groups based on the HKA angle were examined.....................
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